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Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era

1 Jan 2021

Abstract excerpt

Glucocorticoids are potent anti-inflammatory drugs that are used to treat an extraordinary range of human disease, including COVID-19, underscoring the ongoing importance of understanding their molecular mechanisms. Early studies of GR signaling led to broad acceptance of models in which glucocorticoid receptor (GR) monomers tether repressively to inflammatory transcription factors, thus abrogating inflammatory...

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PMID: 33891947
DOI: 10.1016/j.jbc.2021.100687

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