Article
Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
Cell - 12 Jul 2002
Bledsoe Randy K, Montana Valerie G, Stanley Thomas B, Delves Chris J, Apolito Christopher J, McKee David D, Consler Thomas G, Parks Derek J, Stewart Eugene L, Willson Timothy M, Lambert Millard H, Moore John T, Pearce Kenneth H, Xu H Eric
Abstract excerpt
Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermediary factor 2. Despite structural similarity to other steroid receptors, the GR LBD adopts a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.