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How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids

25 May 2022

Abstract excerpt

Glucocorticoids (GCs) are widely used therapeutic agents to treat a broad range of inflammatory conditions. Their functional effects are elicited by binding to the glucocorticoid receptor (GR), which regulates transcription of distinct gene networks in response to ligand. However, the mechanisms governing various aspects of undesired side effects versus beneficial immunomodulation upon GR activation remain...

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PMID: 35612756
DOI: 10.1002/1873-3468.14409

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