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Article

Small molecules that enhance the catalytic efficiency of HLA-DM.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006

Nicholson Melissa J, Moradi Babak, Seth Nilufer P, Xing Xuechao, Cuny Gregory D, Stein Ross L, Wucherpfennig Kai W

Abstract excerpt

HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules. Large lateral surfaces involved in the DM:HLA-DR (DR) interaction have been defined, but the mechanism of catalysis is not understood. In this study, we describe four small molecules that accelerate DM-catalyzed peptide exchange. Mechanistic studies demonstrate that these...

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Identifiers

PMID: 16547258
DOI: 10.4049/jimmunol.176.7.4208
PMCID: PMC3412064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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