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Article

Human Hepatitis B Viral Infection Outcomes Are Linked to Naturally Occurring Variants of HLA-DOA That Have Altered Function.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2020

Graves Austin M, Virdis Francesca, Morrison Eliot, Álvaro-Benito Miguel, Khan Aly A, Freund Christian, Golovkina Tatyana V, Denzin Lisa K

Abstract excerpt

HLA molecules of the MHC class II (MHCII) bind and present pathogen-derived peptides for CD4 T cell activation. Peptide loading of MHCII in the endosomes of cells is controlled by the interplay of the nonclassical MHCII molecules, HLA-DM (DM) and HLA-DO (DO). DM catalyzes peptide loading, whereas DO, an MHCII substrate mimic, prevents DM from interacting with MHCII, resulting in an altered MHCII-peptide...

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Identifiers

PMID: 32690655
DOI: 10.4049/jimmunol.2000476
PMCID: PMC7415708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human Hepatitis B Viral Infection Outcomes Are Linked to Naturally Occurring Variants of HLA-DOA That Have Altered Function.PMID 32690655Read ↗

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.Semantic proximity Read ↗

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