Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tubular p53 Regulates Multiple Genes to Mediate AKI

4 Apr 2014

Abstract excerpt

A pathogenic role of p53 in AKI was suggested a decade ago but remains controversial. Indeed, recent work indicates that inhibition of p53 protects against ischemic AKI in rats but exacerbates AKI in mice. One intriguing possibility is that p53 has cell type-specific roles in AKI. To determine the role of tubular p53, we generated two conditional gene knockout mouse models, in which p53 is specifically ablated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Kidney Injury Research
Share to Chemotherapy-induced organ toxicity mitigation
Share to Tuberous Sclerosis Complex Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24700871
DOI: 10.1681/asn.2013080902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tubular p53 Regulates Multiple Genes to Mediate AKIPMID 24700871Read ↗

p53 is renoprotective after ischemic kidney injury by reducing inflammation.Semantic proximity Read ↗

p53 activates miR-192-5p to mediate vancomycin induced AKISemantic proximity Read ↗

Functional TauT Protects Against Acute Kidney InjurySemantic proximity Read ↗

Chronic kidney disease and aging: dissecting the p53/p21 pathway as a therapeutic targetSemantic proximity Read ↗

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo.Semantic proximity Read ↗

Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responsesSemantic proximity Read ↗

Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.Semantic proximity Read ↗

Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury.Semantic proximity Read ↗

UNC5B receptor deletion exacerbates tissue injury in response to AKI.Semantic proximity Read ↗

MG53-mediated cell membrane repair protects against acute kidney injury.Semantic proximity Read ↗

Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.Semantic proximity Read ↗

Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.