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Article

p53 activates miR-192-5p to mediate vancomycin induced AKI

12 Dec 2016

Abstract excerpt

Pathogenic role of p53 in AKI remains controversial and the underlying mechanism is unclear. Here, we tested whether the inhibition of p53 may ameliorate vancomycin (VAN) induced acute kidney injury (AKI). Mice with p53 knock out (p53-KO) were resistant to VAN induced AKI, indicated by the analysis of renal function, histology, and apoptosis. Mechanistically, AKI was associated with the upregulation of several...

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PMID: 27941921
DOI: 10.1038/srep38868

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