Article
Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy.
Journal of the American Society of Nephrology : JASN - 1 Feb 2014
Lech Maciej, Gröbmayr Regina, Ryu Mi, Lorenz Georg, Hartter Ingo, Mulay Shrikant R, Susanti Heni Eka, Kobayashi Koichi S, Flavell Richard A, Anders Hans-Joachim
Abstract excerpt
The mechanisms that determine full recovery versus subsequent progressive CKD after AKI are largely unknown. Because macrophages regulate inflammation as well as epithelial recovery, we investigated whether macrophage activation influences AKI outcomes. IL-1 receptor-associated kinase-M (IRAK-M) is a macrophage-specific inhibitor of Toll-like receptor (TLR) and IL-1 receptor signaling that prevents polarization...
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