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Article

Distinct macrophage phenotypes contribute to kidney injury and repair.

Journal of the American Society of Nephrology : JASN - 1 Feb 2011

Lee Sik, Huen Sarah, Nishio Hitoshi, Nishio Saori, Lee Heung Kyu, Choi Bum-Soon, Ruhrberg Christiana, Cantley Lloyd G

Abstract excerpt

The ischemically injured kidney undergoes tubular cell necrosis and apoptosis, accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos-positive proinflammatory (M1) macrophages are recruited into the kidney in the first 48 hours after ischemia/reperfusion injury, whereas arginase 1- and mannose receptor-positive, noninflammatory (M2) macrophages predominate at later time...

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Source

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Identifiers

PMID: 21289217
DOI: 10.1681/ASN.2009060615
PMCID: PMC3029904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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