Article
Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2013
Walsh Kyle M, Gorlov Ivan P, Hansen Helen M, Wu Xifeng, Spitz Margaret R, Zhang Huifeng, Lu Emily Y, Wenzlaff Angela S, Sison Jennette D, Wei Chongjuan, Lloyd Stacy M, Chen Wei, Frazier Marsha L, Seldin Michael F, Bierut Laura J, Bracci Paige M, Wrensch Margaret R, Schwartz Ann G, Wiencke John K, Amos Christopher I
Abstract excerpt
BACKGROUND: Genome-wide association studies of European and East Asian populations have identified lung cancer susceptibility loci on chromosomes 5p15.33, 6p22.1-p21.31, and 15q25.1. We investigated whether these regions contain lung cancer susceptibly loci in African-Americans and refined previous association signals by using the reduced linkage disequilibrium observed in African-Americans. METHODS: 1,308...
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