Article
Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci.
Carcinogenesis - 1 Jan 2016
Kachuri Linda, Amos Christopher I, McKay James D, Johansson Mattias, Vineis Paolo, Bueno-de-Mesquita H Bas, Boutron-Ruault Marie-Christine, Johansson Mikael, Quirós J Ramón, Sieri Sabina, Travis Ruth C, Weiderpass Elisabete, Le Marchand Loic, Henderson Brian E, Wilkens Lynne, Goodman Gary E, Chen Chu, Doherty Jennifer A, Christiani David C, Wei Yongyue, Su Li, Tworoger Shelley, Zhang Xuehong, Kraft Peter, Zaridze David, Field John K, Marcus Michael W, Davies Michael P A, Hyde Russell, Caporaso Neil E, Landi Maria Teresa, Severi Gianluca, Giles Graham G, Liu Geoffrey, McLaughlin John R, Li Yafang, Xiao Xiangjun, Fehringer Gord, Zong Xuchen, Denroche Robert E, Zuzarte Philip C, McPherson John D, Brennan Paul, Hung Rayjean J
Abstract excerpt
Chromosome 5p15.33 has been identified as a lung cancer susceptibility locus, however the underlying causal mechanisms were not fully elucidated. Previous fine-mapping studies of this locus have relied on imputation or investigated a small number of known, common variants. This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their...
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