Article
Lung cancer susceptibility locus at 5p15.33.
Nature genetics - 1 Dec 2008
McKay James D, Hung Rayjean J, Gaborieau Valerie, Boffetta Paolo, Chabrier Amelie, Byrnes Graham, Zaridze David, Mukeria Anush, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Bencko Vladimir, Foretova Lenka, Janout Vladimir, McLaughlin John, Shepherd Frances, Montpetit Alexandre, Narod Steven, Krokan Hans E, Skorpen Frank, Elvestad Maiken Bratt, Vatten Lars, Njølstad Inger, Axelsson Tomas, Chen Chu, Goodman Gary, Barnett Matt, Loomis Melissa M, Lubiñski Jan, Matyjasik Joanna, Lener Marcin, Oszutowska Dorota, Field John, Liloglou Triantafillos, Xinarianos George, Cassidy Adrian, Vineis Paolo, Clavel-Chapelon Francoise, Palli Domenico, Tumino Rosario, Krogh Vittorio, Panico Salvatore, González Carlos A, Ramón Quirós José, Martínez Carmen, Navarro Carmen, Ardanaz Eva, Larrañaga Nerea, Kham Kay Tee, Key Timothy, Bueno-de-Mesquita H Bas, Peeters Petra Hm, Trichopoulou Antonia, Linseisen Jakob, Boeing Heiner, Hallmans Göran, Overvad Kim, Tjønneland Anne, Kumle Merethe, Riboli Elio, Zelenika Diana, Boland Anne, Delepine Marc, Foglio Mario, Lechner Doris, Matsuda Fumihiko, Blanche Helene, Gut Ivo, Heath Simon, Lathrop Mark, Brennan Paul
Abstract excerpt
We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two...