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Article

Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.

Carcinogenesis - 1 Feb 2010

Wang Yufei, Broderick Peter, Matakidou Athena, Eisen Timothy, Houlston Richard S

Abstract excerpt

Genome-wide association studies have provided evidence that common variation at 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk. To examine if variation at any of these loci influences the risk of lung cancer in never-smokers, we compared 5p15.33-TERT (rs2736100), 5p15.33-CLPTM1L (rs4975616), 6p21.33-BAT3 (rs3117582), 15q25.1-CHRNA3 (rs8042374) and 15q25.1-CHRNA3...

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Source

Identifiers

PMID: 19955392
DOI: 10.1093/carcin/bgp287

Genes

CHRNA3
TERT
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.PMID 19955392Read ↗

The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.Semantic proximity Read ↗

Lung cancer susceptibility locus at 5p15.33.Semantic proximity Read ↗

Common 5p15.33 and 6p21.33 variants influence lung cancer risk.Semantic proximity Read ↗

Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population.Semantic proximity Read ↗

Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.Semantic proximity Read ↗

TERT-rs33963617 and CLPTM1L-rs77518573 reduce the risk of non-small cell lung cancer in Chinese population.Semantic proximity Read ↗

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.Semantic proximity Read ↗

The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema.Semantic proximity Read ↗

Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population.Semantic proximity Read ↗

Study of genetic variants in chromosome 5p15.33 region in non-smoker lung cancer patients.Semantic proximity Read ↗

A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC).Semantic proximity Read ↗

Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.Semantic proximity Read ↗

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