Common 5p15.33 and 6p21.33 variants influence lung cancer risk.

doi:10.1038/ng.273

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Article

Common 5p15.33 and 6p21.33 variants influence lung cancer risk.

Nature genetics - 1 Dec 2008

Wang Yufei, Broderick Peter, Webb Emily, Wu Xifeng, Vijayakrishnan Jayaram, Matakidou Athena, Qureshi Mobshra, Dong Qiong, Gu Xiangjun, Chen Wei Vivien, Spitz Margaret R, Eisen Timothy, Amos Christopher I, Houlston Richard S

Abstract excerpt

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 x 10(-12)), confirming recent observations. Pooling data with two other GWA studies (5...

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PMID: 18978787
DOI: 10.1038/ng.273
PMCID: PMC2695928

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MSH5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18978787-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Common 5p15.33 and 6p21.33 variants influence lung cancer risk.PMID 18978787Read ↗

Lung cancer susceptibility locus at 5p15.33.Semantic proximity Read ↗

Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.Semantic proximity Read ↗

Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.Semantic proximity Read ↗

Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.Semantic proximity Read ↗

The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.Semantic proximity Read ↗

Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.Semantic proximity Read ↗

Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population.Semantic proximity Read ↗

Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk.Semantic proximity Read ↗

A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC).Semantic proximity Read ↗

Replication study in Chinese population and meta-analysis supports association of the 5p15.33 locus with lung cancer.Semantic proximity Read ↗

Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.Semantic proximity Read ↗

A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.Semantic proximity Read ↗

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