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Article

Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans.

Human molecular genetics - 15 Sept 2010

Hansen Helen M, Xiao Yuanyuan, Rice Terri, Bracci Paige M, Wrensch Margaret R, Sison Jennette D, Chang Jeffery S, Smirnov Ivan V, Patoka Joseph, Seldin Michael F, Quesenberry Charles P, Kelsey Karl T, Wiencke John K

Abstract excerpt

Several genome-wide association studies identified the chr15q25.1 region, which includes three nicotinic cholinergic receptor genes (CHRNA5-B4) and the cell proliferation gene (PSMA4), for its association with lung cancer risk in Caucasians. A haplotype and its tagging single nucleotide polymorphisms (SNPs) encompassing six genes from IREB2 to CHRNB4 were most strongly associated with lung cancer risk (OR = 1.3;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20587604
DOI: 10.1093/hmg/ddq268
PMCID: PMC2928127

Genes

CHRNA5
CHRNB4
PSMA4
CHRNA3

Provenance

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