Vanillin differentially affects azoxymethane-injected rat colon carcinogenesis and gene expression.

doi:10.1089/jmf.2012.2245

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Article

Vanillin differentially affects azoxymethane-injected rat colon carcinogenesis and gene expression.

Journal of medicinal food - 1 Dec 2012

Ho Ket Li, Chong Pei Pei, Yazan Latifah Saiful, Ismail Maznah

Abstract excerpt

Vanillin is the substance responsible for the flavor and smell of vanilla, a widely used flavoring agent. Previous studies reported that vanillin is a good antimutagen and anticarcinogen. However, there are also some contradicting findings showing that vanillin was a comutagen and cocarcinogen. This study investigated whether vanillin is an anticarcinogen or a cocarcinogen in rats induced with azoxymethane (AOM)....

Topics

Aberrant Crypt Foci
Animals
Anticarcinogenic Agents
Apoptosis
Azoxymethane
Benzaldehydes
Cell Cycle
Cell Transformation, Neoplastic
Colon
Colorectal Neoplasms
DNA Mismatch Repair
Gene Expression
Male
Mutation
Rats
Rats, Sprague-Dawley

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Identifiers

PMID: 23216109
DOI: 10.1089/jmf.2012.2245
PMCID: PMC3523249

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