Article
Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model.
Journal of gastroenterology and hepatology - 1 Oct 2013
Tsuda Miho, Okamoto Koichi, Muguruma Naoki, Sannomiya Katsutaka, Nakagawa Tadahiko, Miyamoto Hiroshi, Kitamura Shinji, Goji Takahiro, Kimura Tetsuo, Okahisa Toshiya, Izumi Keisuke, Takayama Tetsuji
Abstract excerpt
BACKGROUND AND AIM: The chemopreventive effect of RAS inhibitors on colorectal cancer is unknown. Because aberrant crypt foci (ACF), earliest preneoplastic lesions, are highly positive for K-RAS mutation, RAS inhibitors are likely to be effective for chemoprevention. Therefore, in the present study, the suppressive effect of a RAS inhibitor, manumycin A, on ACF formation in an azoxymethane (AOM)-induced rat...
Topics
- Aberrant Crypt Foci
- Animals
- Apoptosis
- Azoxymethane
- Colorectal Neoplasms
- Disease Models, Animal
- Enzyme Inhibitors
- Extracellular Signal-Regulated MAP Kinases
- Farnesyltranstransferase