Article
Functional genomics of the rat neuromedin U receptor 1 reveals a naturally occurring deleterious allele.
Physiological genomics - 15 Jan 2013
Panetta Rosemarie, Meury Luc, Cao Chang Qing, Puma Carole, Mennicken Françoise, Cassar Paul A, Laird Jennifer, Groblewski Thierry
Abstract excerpt
Neuromedin U (NMU) plays an important role in a number of physiological processes, but the relative contribution of its two known receptors, NMUR1 and NMUR2, is still poorly understood. Here we report the existence of a SNP T(1022)→A (Val(341)→Glu) in the third exon of the rat Nmur1 gene that leads to an inactive receptor. This SNP is present within the coding region of the highly conserved NPXXY motif found...
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