Article
The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.
British journal of clinical pharmacology - 1 Jun 2013
Ahlers Sabine J G M, Elens Laure L, van Gulik Laura, van Schaik Ron H, van Dongen Eric P A, Bruins Peter, Tibboel Dick, Knibbe Catherijne A J
Abstract excerpt
AIMS: The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown; therefore, the aim of this study was to investigate whether the COMT Val158Met polymorphism increases pain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.