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Article

Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism.

PloS one - 23 Jun 2009

Jensen Karin B, Lonsdorf Tina B, Schalling Martin, Kosek Eva, Ingvar Martin

Abstract excerpt

Increased pain sensitivity after opioid administration (opioid-induced hyperalgesia) and/or repeated painful stimuli is an individually varying and clinically important phenomenon. The functional polymorphism (val(158)met) of the Catechol-O-methyltransferase (COMT) gene regulates the metabolism of dopamine/noradrenaline. Individuals homozygous for the met(158) allele have been reported to have increased pain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19547755
DOI: 10.1371/journal.pone.0006016
PMCID: PMC2695541

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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