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Article

OPRM1 and COMT polymorphisms: implications on postoperative acute, chronic and experimental pain after cardiac surgery.

Pharmacogenomics - 1 Feb 2020

Matic Maja, de Hoogd Sjoerd, de Wildt Saskia N, Tibboel Dick, Knibbe Catherijne Aj, van Schaik Ron Hn

Abstract excerpt

Aim: Investigate the potential role of OPRM1 (mu-opioid receptor) and COMT (catechol-O-methyltransferase enzyme) polymorphisms in postoperative acute, chronic and experimental thermal pain. Methods: A secondary analysis of 125 adult cardiac surgery patients that were randomized between fentanyl and remifentanil during surgery and genotyped. Results: Patients in the fentanyl group with the COMT high-pain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31967515
DOI: 10.2217/pgs-2019-0141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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