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Chronic persistent surgical pain is strongly associated with COMT alleles in patients undergoing cardiac surgery with median sternotomy.

General thoracic and cardiovascular surgery - 1 Oct 2020

Dharaniprasad Goduguchintha, Samantaray Aloka, Srikanth Lokanathan, Hanumantha Rao Mangu, Chandra Abha, Sarma Potukuchi Venktata Gurunadha Krishna

Abstract excerpt

OBJECTIVES: Catechol-O-methyl transferase (COMT), a catechol-dependent enzyme, plays pivotal role in the development of pain. In different ethnic populations, it is associated with chronic persistent surgical pain (CPSP). In this context, the present study is aimed to assess involvement of COMT allele (Val158Met) in the development of CPSP. METHODOLOGY: The patients (n = 216) underwent cardiac surgery with median...

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PMID: 32100171
DOI: 10.1007/s11748-020-01321-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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