Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of the α(2c)-adrenoceptor Del322-325 allele is associated with increased mortality in patients with chronic systolic heart failure.

Journal of cardiac failure - 1 Dec 2012

Amir Offer, Smith Yoav, Zafrir Barak, Azzam Naiel, Lewis Basil S, Fares Fuad

Abstract excerpt

OBJECTIVE: The Del322-325 polymorphism of the α(2c)-adrenoceptor is considered to be a possible risk factor for heart failure (HF). We investigated the possible clinical association between the presence or absence of the deletion allele and mortality. METHODS AND RESULTS: Of 261 chronic systolic HF patients evaluated, 216 (83%) carried no α(2c)-adrenoceptor Del322-325 alleles (designated II); 28 patients (11%)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Heterozygote

Share to Homozygote

Share to Polymerase Chain Reaction

Share to Receptors, Adrenergic, alpha-2

Share to Sequence Deletion

Source

Identifiers

PMID: 23207081
DOI: 10.1016/j.cardfail.2012.10.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of the α(2c)-adrenoceptor Del322-325 allele is associated with increased mortality in patients with chronic systolic heart failure.PMID 23207081Read ↗

Polymorphisms of adrenoceptors are not associated with an increased risk of adverse event in heart failure: a MERIT-HF substudy.Semantic proximity Read ↗

Role of beta1- and alpha2c-adrenergic receptor polymorphisms and their combination in heart failure: a case-control study.Semantic proximity Read ↗

No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population.Semantic proximity Read ↗

Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy.Semantic proximity Read ↗

The alpha 2C Del322-325 adrenergic receptor polymorphism is not associated with heart failure due to idiopathic dilated cardiomyopathy in black Africans.Semantic proximity Read ↗

Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients.Semantic proximity Read ↗

Ile164 variant of beta2-adrenoceptor does not influence outcome in heart failure but may interact with beta blocker treatment.Semantic proximity Read ↗

Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.Semantic proximity Read ↗

Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry.Semantic proximity Read ↗

Relation of β2-Adrenoceptor Haplotype to Risk of Death and Heart Transplantation in Patients With Heart FailureSemantic proximity Read ↗

Impact of beta-2 Thr164Ile and combined beta-adrenergic receptor polymorphisms on prognosis in a cohort of heart failure outpatients.Semantic proximity Read ↗

Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.