Article
Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry.
Cardiovascular journal of Africa - 1 Jan 2000
Woodiwiss A J, Badenhorst D, Sliwa K, Brooksbank R, Essop R, Sareli P, Norton G R
Abstract excerpt
BACKGROUND: Although the beta1-adrenoreceptor (AR) Gly389Arg and alpha2c-AR Del322-325 gene variants are associated with the response to beta-AR-blocker therapy, whether this effect is associated with the risk for heart failure, or the severity or progression of heart failure is uncertain. AIMS: To assess the relationship between Gly389Arg and Del322-325 variants and the presence, severity and progression of...
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