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Article

Role of beta1- and alpha2c-adrenergic receptor polymorphisms and their combination in heart failure: a case-control study.

European journal of heart failure - 1 Mar 2006

Metra Marco, Zani Claudia, Covolo Loredana, Nodari Savina, Pezzali Natalia, Gelatti Umberto, Donato Francesco, Nardi Giuseppe, Dei Cas Livio

Abstract excerpt

BACKGROUND: Adrenergic activation has a central role in the development of HF. The function of the beta1- and the alpha2C-adrenergic receptors is influenced by gene polymorphisms: the beta1Arg389 variant is associated with increased beta1-receptor sensitivity and the alpha2C-receptor Del322-325 variant is associated with decreased alpha2C receptor function and increased norepinephrine release. We hypothesised...

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Identifiers

PMID: 16188498
DOI: 10.1016/j.ejheart.2005.07.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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