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Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.

The New England journal of medicine - 10 Oct 2002

Small Kersten M, Wagoner Lynne E, Levin Albert M, Kardia Sharon L R, Liggett Stephen B

Abstract excerpt

BACKGROUND: Sustained cardiac adrenergic stimulation has been implicated in the development and progression of heart failure. Release of norepinephrine is controlled by negative feedback from presynaptic alpha2-adrenergic receptors, and the targets of the released norepinephrine on myocytes are beta1-adrenergic receptors. In transfected cells, a polymorphic alpha2C-adrenergic receptor (alpha2CDel322-325) has...

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Heart Failure
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Receptors, Adrenergic, alpha-2

Receptors, Adrenergic, beta-1

Survival Analysis

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PMID: 12374873
DOI: 10.1056/NEJMoa020803

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