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Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy.

European heart journal - 1 Feb 2006

Regitz-Zagrosek Vera, Hocher Berthold, Bettmann Martin, Brede Marc, Hadamek Kerstin, Gerstner Carolin, Lehmkuhl Hans Brendan, Hetzer Roland, Hein Lutz

Abstract excerpt

AIMS: The sympathetic nervous system plays a central role in cardiac growth but its overstimulation is associated with increased mortality in patients with chronic heart failure. Pre-synaptic alpha2-adrenoceptors are essential feedback regulators to control the release of norepinephrine from sympathetic nerves. In this study we tested whether a deletion polymorphism in the human alpha2C-adrenoceptor gene...

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Cardiac Pacing, Artificial
Cardiomyopathy, Dilated
Disease-Free Survival
Heart Failure
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Adrenergic, alpha-2

Regression Analysis

Survival Analysis

Source

Identifiers

PMID: 16299019
DOI: 10.1093/eurheartj/ehi659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy.PMID 16299019Read ↗

No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population.Semantic proximity Read ↗

Insertion/deletion polymorphism in alpha2-adrenergic receptor gene is a genetic risk factor for sudden cardiac death.Semantic proximity Read ↗

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Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy.Semantic proximity Read ↗

Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.Semantic proximity Read ↗

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Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.Semantic proximity Read ↗

Absence of the α(2c)-adrenoceptor Del322-325 allele is associated with increased mortality in patients with chronic systolic heart failure.Semantic proximity Read ↗

Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects.Semantic proximity Read ↗

Polymorphisms of the beta-1 and beta-2 adrenergic receptors in Polish patients with idiopathic dilated cardiomyopathy.Semantic proximity Read ↗

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