Article
Polymorphisms of adrenoceptors are not associated with an increased risk of adverse event in heart failure: a MERIT-HF substudy.
Journal of cardiac failure - 1 Jun 2009
Savva Jacqueline, Maqbool Azhar, White Hazel L, Galloway Stacey L, Yuldasheva Nadira Y, Ball Stephen G, West Robert M, De Boer Rudolf A, Van Veldhuisen Dirk J, Balmforth Anthony J
Abstract excerpt
BACKGROUND: Enhanced sympathetic activation has a central role in the development of heart failure (HF). We assessed whether the alpha(2C)-adrenoceptor (Del322-325) polymorphism exclusively or in combination with a beta(1)-adrenoceptor (Arg389) polymorphism, each with known independent effects on sympathetic function, were associated with an increased risk of adverse events in HF. METHODS AND RESULTS: A total of...
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