Article
Characterization of CD4+CD8+ thymocytes observed in SCID-bg mice.
Immunology and cell biology - 1 Oct 1997
Shibata S, Asano T, Noguchi A, Kimura H, Hashimoto N, Hayakawa J, Ogura A, Doi K
Abstract excerpt
Previously, we reported that a strain of severe combined immunodeficient (SCID) mice, namely SCID-bg, spontaneously develop CD4+CD8+ double positive (DP) thymocytes despite their scid mutation. In the present study, we intend to further characterize the DP thymocyte population in SCID-bg mice wit...
Topics
- Animals
- Blotting, Southern
- CD4 Antigens
- CD8 Antigens
- Flow Cytometry
- Gene Rearrangement, T-Lymphocyte
- Genes, T-Cell Receptor beta
- Genes, T-Cell Receptor gamma
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Phenotype
- Proto-Oncogene Proteins c-bcl-2
- Receptors, Antigen, T-Cell
- Receptors, Interleukin-2
- T-Lymphocyte Subsets
- T-Lymphocytes