Article
VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer.
Molecular immunology - 1 Aug 1994
Riggs J E, Feeney A J, Kirven M, Mosier D E
Abstract excerpt
The scid mutation interferes with normal rearrangement of antigen receptor genes, leading to an absence of T and B lymphocytes in most SCID mice. However, the SCID phenotype is "leaky", with an age- and strain-dependent increase in the incidence of mice with small number of T and B cells and read...
Topics
- Animals
- Antibody-Producing Cells
- Base Sequence
- Enzyme-Linked Immunosorbent Assay
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- T-Lymphocytes