Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TCR beta-independent development of CD4+ CD8+ thymocytes observed in a strain of scid mice.

Immunology and cell biology - 1 Apr 1997

Shibata S, Asano T, Ogura A, Hashimoto N, Hayakawa J, Naiki M, Doi K

Abstract excerpt

Mice homozygous for severe combined immunodeficiency (scid) mutation usually halt their thymocyte development at the CD4-CD8- double negative (DN) stage due to their inability of TCR gene rearrangement. In this study, we report that SCID-bg mice, which were originally generated by mating CB-17-scid mice with KSN-bg mice, spontaneously develop dominant CD4+ CD8+ double positive (DP) thymocytes. Their thymi were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to CD4-Positive T-Lymphocytes
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Phenotype

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Spleen

Source

Identifiers

PMID: 9107568
DOI: 10.1038/icb.1997.21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TCR beta-independent development of CD4+ CD8+ thymocytes observed in a strain of scid mice.PMID 9107568Read ↗

Characterization of CD4+CD8+ thymocytes observed in SCID-bg mice.Semantic proximity Read ↗

CD8+ T cells induce medullary thymic epithelium and CD4+CD8+CD25+ TCRbeta- thymocytes in SCID mice.Semantic proximity Read ↗

Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes.Semantic proximity Read ↗

TGF-β type II receptor–deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivoSemantic proximity Read ↗

Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis.Semantic proximity Read ↗

Simplified method of identifying severe combined immunodeficient (SCID) mice versus non-SCID mice by flow cytometric analysis of peripheral blood.Semantic proximity Read ↗

Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.Semantic proximity Read ↗

Characterization of V beta-bearing cells in athymic (nu/nu) mice suggests an extrathymic pathway for T cell differentiation.Semantic proximity Read ↗

Phenotypically distinct subsets of CD4<sup>+</sup> T cells induce or protect from chronic intestinal inflammation in C. B-17 <i>scid</i> miceSemantic proximity Read ↗

Development of T cells in SCID mice grafted with fetal thymus from AKR mice or F344 rats.Semantic proximity Read ↗

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.Semantic proximity Read ↗

TCR-beta chains derived from peripheral gammadelta T cells can take part in alphabeta T-cell development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.