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Article

TCR beta-independent development of CD4+ CD8+ thymocytes observed in a strain of scid mice.

Immunology and cell biology - 1 Apr 1997

Shibata S, Asano T, Ogura A, Hashimoto N, Hayakawa J, Naiki M, Doi K

Abstract excerpt

Mice homozygous for severe combined immunodeficiency (scid) mutation usually halt their thymocyte development at the CD4-CD8- double negative (DN) stage due to their inability of TCR gene rearrangement. In this study, we report that SCID-bg mice, which were originally generated by mating CB-17-sc...

Topics

Animals
Bone Marrow
Bone Marrow Cells
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Flow Cytometry
Mice
Mice, Inbred BALB C
Mice, SCID
Phenotype
Receptors, Antigen, T-Cell, alpha-beta
Spleen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9107568
DOI: 10.1038/icb.1997.21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9107568-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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