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Article

Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus.

Atherosclerosis - 1 Apr 2013

Zollbrecht Christa, Grassl Martina, Fenk Sabine, Höcherl Regina, Hubauer Ute, Reinhard Wibke, Esslinger Ulrike B, Ebert Stefanie, Langmann Thomas, Stark Klaus, Hengstenberg Christian

Abstract excerpt

OBJECTIVE: Genome-wide association studies identified a risk haplotype on chromosome 9p21.3 to be associated with coronary artery disease (CAD) and myocardial infarction (MI). Since this region does not contain a clear candidate gene with known pathophysiology, we performed a haplotype-specific expression study in human macrophages during pro-inflammatory stimulation to investigate the locus-dependent expression...

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Identifiers

PMID: 23375685
DOI: 10.1016/j.atherosclerosis.2012.12.030

Genes

CAD
CCL2
CCL8

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