Article
Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury.
PloS one - 1 Jan 2013
Rojas Modesto, Zhang Wenbo, Xu Zhimin, Lemtalsi Tahira, Chandler Phillip, Toque Haroldo A, Caldwell Robert W, Caldwell Ruth B
Abstract excerpt
OBJECTIVE: Diabetic retinopathy, a major cause of blindness, is characterized by increased expression of vascular endothelial growth factor (VEGF), leukocyte attachment to the vessel walls and increased vascular permeability. Previous work has shown that reactive oxygen species (ROS) produced by the superoxide generating enzyme NOX2/NADPH oxidase play a crucial role in the vascular pathology. The aim of this work...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.