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Article

Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.

Circulation - 18 Nov 2008

Wang Chao-Yung, Wen Ming-Shien, Wang Hong-Wei, Hsieh I-Chang, Li Yuxin, Liu Ping-Yen, Lin Fun-Chung, Liao James K

Abstract excerpt

BACKGROUND: Alteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction in Per2 mutant (Per2(m/m)) mice is mediated in part by increased vascular senescence and...

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Identifiers

PMID: 18981300
DOI: 10.1161/CIRCULATIONAHA.108.790469
PMCID: PMC2656770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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