Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-related alterations in retinal structure and blood perfusion in TIPE2 gene-knockout mice.

Experimental eye research - 1 Mar 2026

Han Xinyao, Wu Tiexi, Si Wenyi, Zhang Lu, Jiang Shiyu, Liu Suxia, Qin Xuejiao

Abstract excerpt

Tumor necrosis factor-α-induced protein 8-like 2 (TNFAIP8L2/TIPE2) is a critical regulator of immune and inflammatory responses. Although its roles in diabetic retinopathy and choroidal neovascularization have been reported, its influence on the natural state of retina remains unclear. This study investigated whether TIPE2 knockout alone affects retinal structure and function. Wild-type (WT) and TIPE2-/- mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Fluorescein Angiography
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Regional Blood Flow

Share to Retina

Share to Retinal Vessels

Share to Tomography, Optical Coherence

Source

Identifiers

PMID: 41475632
DOI: 10.1016/j.exer.2025.110834

Genes

TIPE2
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-related alterations in retinal structure and blood perfusion in TIPE2 gene-knockout mice.PMID 41475632Read ↗

Endothelial ANGPT2 insufficiency impairs retinal vascularization with ROP-like neovascular tuftsSemantic proximity Read ↗

High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut MicrobiotaSemantic proximity Read ↗

Single-cell transcriptomics-based multidisease analysis revealing the molecular dynamics of retinal neurovascular units under inflammatory and hypoxic conditionsSemantic proximity Read ↗

A review of the multifunctionality of angiopoietin-like 4 in eye diseaseSemantic proximity Read ↗

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip.Semantic proximity Read ↗

Atypical p38 Kinase Signaling in Retinal Vascular Damage and RecoverySemantic proximity Read ↗

Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathySemantic proximity Read ↗

Revisiting the mouse model of oxygen-induced retinopathySemantic proximity Read ↗

Endothelin 2–Mediated Neuroinflammation Drives Hypertension-Associated Retinal DysfunctionSemantic proximity Read ↗

Animal Models of Retinopathy of Prematurity: Advances and Metabolic RegulatorsSemantic proximity Read ↗

Retinal vasculature development in health and diseaseSemantic proximity Read ↗

Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.