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Article

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.

The Journal of biological chemistry - 25 Jan 2013

Vartanian Steffan, Bentley Carolyn, Brauer Matthew J, Li Li, Shirasawa Senji, Sasazuki Takehiko, Kim Jung-Sik, Haverty Pete, Stawiski Eric, Modrusan Zora, Waldman Todd, Stokoe David

Abstract excerpt

To assess the consequences of endogenous mutant K-Ras, we analyzed the signaling and biological properties of a small panel of isogenic cell lines. These include the cancer cell lines DLD1, HCT116, and Hec1A, in which either the WT or mutant K-ras allele has been disrupted, and SW48 colorectal cancer cells and human mammary epithelial cells in which a single copy of mutant K-ras was introduced at its endogenous...

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Identifiers

PMID: 23188824
DOI: 10.1074/jbc.M112.394130
PMCID: PMC3554910

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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