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Article

The role of wild type RAS isoforms in cancer.

Seminars in cell & developmental biology - 1 Oct 2016

Zhou Bingying, Der Channing J, Cox Adrienne D

Abstract excerpt

Mutationally activated RAS proteins are critical oncogenic drivers in nearly 30% of all human cancers. As with mutant RAS, the role of wild type RAS proteins in oncogenesis, tumour maintenance and metastasis is context-dependent. Complexity is introduced by the existence of multiple RAS genes (HRAS, KRAS, NRAS) and protein "isoforms" (KRAS4A, KRAS4B), by the ever more complicated network of RAS signaling, and by...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27422332
DOI: 10.1016/j.semcdb.2016.07.012
PMCID: PMC5028303

Genes

KRAS
NRAS
HRAS

Provenance

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