Oncogenic K-ras “addiction” and synthetic lethality

Abstract excerpt

Mutational activation of the K-ras gene is a frequent oncogenic event in human cancers, associated with poor clinical prognosis and resistance to treatment.Despite efforts to develop therapeutics that target K-ras or its downstream effector molecules, clinical benefit in this setting has not yet been achieved.An alternative approach to K-ras mutant cancers involves the identification of genes that selectively...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Chronic Lymphocytic Leukemia Research
• Share to Metabolism, Diabetes, and Cancer