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Article

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.

Cancer research - 15 Sept 2007

Konishi Hiroyuki, Karakas Bedri, Abukhdeir Abde M, Lauring Josh, Gustin John P, Garay Joseph P, Konishi Yuko, Gallmeier Eike, Bachman Kurtis E, Park Ben Ho

Abstract excerpt

The oncogenic function of mutant ras in mammalian cells has been extensively investigated using multiple human and animal models. These systems include overexpression of exogenous mutant ras transgenes, conditionally expressed knock-in mouse models, and somatic cell knockout of mutant and wild-type ras genes in human cancer cell lines. However, phenotypic discrepancies between knock-in mice and transgenic mutant...

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PMID: 17875684
DOI: 10.1158/0008-5472.CAN-07-0108

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