Article
The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
Molecular carcinogenesis - 1 Feb 2017
Matsunaga Yasutaka, Adachi Yasushi, Sasaki Yasushi, Koide Hideyuki, Motoya Masayo, Nosho Katsuhiko, Takagi Hideyasu, Yamamoto Hiroyuki, Sasaki Shigeru, Arimura Yoshiaki, Tokino Takashi, Carbone David P, Imai Kohzoh, Shinomura Yasuhisa
Abstract excerpt
Mutation in K-RAS (K-RAS-MT) plays important roles in both cancer progression and resistance to anti-epidermal growth factor receptor (EGFR) therapy in gastrointestinal tumors. Insulin-like growth factor-1 receptor (IGF-1R) signaling is required for carcinogenicity and progression of many tumors as well. We have previously shown successful therapy for gastrointestinal cancer cell lines bearing a K-RAS mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.