Article

Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice

2020-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Glycogen synthase kinase (GSK) 3 acts to negatively regulate multiple signaling pathways, including canonical Wnt signaling. The two mammalian GSK3 proteins (alpha and beta) are at least partially redundant. While Gsk3a KO mice are viable and display a metabolic phenotype, abnormal neuronal development and accelerated aging, Gsk3b KO animals die late in embryogenesis or at birth. Selective Gs...

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Literature Corpus work: 89952e74-47e1-5537-ad16-07c9e7f733d6
DOI: 10.1101/2020.04.04.025700

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