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Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

19 Nov 2009

Abstract excerpt

BACKGROUND: Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by two genes that generate two related proteins: GSK-3alpha and GSK-3beta. Mice lacking a functional GSK-3alpha gene were engineered in our laboratory; they are viable and display insulin sensitivity. In this study, we have characterized brain functions of GSK-3alpha KO mice by using a...

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PMID: 19925672
DOI: 10.1186/1756-6606-2-35

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