Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme.

PloS one - 1 Jan 2011

Nelson Emily R, Levi Benjamin, Sorkin Michael, James Aaron W, Liu Karen J, Quarto Natalina, Longaker Michael T

Abstract excerpt

INTRODUCTION: The function of Glycogen Synthase Kinases 3β (GSK-3β) has previously been shown to be necessary for normal secondary palate development. Using GSK-3ß null mouse embryos, we examine the potential coordinate roles of Wnt and Hedgehog signaling on palatal ossification. METHODS: Palates were harvested from GSK-3β, embryonic days 15.0-18.5 (e15.0-e18.5), and e15.5 Indian Hedgehog (Ihh) null embryos, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycogen Synthase Kinase 3
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Mesoderm

Share to Organogenesis

Share to Osteogenesis

Share to Palate

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 22022457
DOI: 10.1371/journal.pone.0025847
PMCID: PMC3194817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme.PMID 22022457Read ↗

Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in miceSemantic proximity Read ↗

The A-kinase Anchoring Protein GSKIP Regulates GSK3β Activity and Controls Palatal Shelf Fusion in Mice.Semantic proximity Read ↗

Ectopic Hedgehog Signaling Causes Cleft Palate and Defective Osteogenesis.Semantic proximity Read ↗

Novel reporter alleles of GSK-3α and GSK-3β.Semantic proximity Read ↗

Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development.Semantic proximity Read ↗

Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice.Semantic proximity Read ↗

GSK3β Rephosphorylation Rescues ALPL Deficiency Induced-impairment of Odontoblastic Differentiation of DPSCsSemantic proximity Read ↗

The Pax9/Wnt pathway regulates secondary palate formation in miceSemantic proximity Read ↗

CTGF mediates Smad-dependent transforming growth factor β signaling to regulate mesenchymal cell proliferation during palate development.Semantic proximity Read ↗

GSK-3 is a master regulator of neural progenitor homeostasis.Semantic proximity Read ↗

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.Semantic proximity Read ↗

Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.