Article
Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation.
FEBS letters - 20 Apr 2011
Alon Lina Tsaadon, Pietrokovski Shmuel, Barkan Shay, Avrahami Limor, Kaidanovich-Beilin Oksana, Woodgett James R, Barnea Anat, Eldar-Finkelman Hagit
Abstract excerpt
Mammalian glycogen synthase kinase-3 (GSK-3), a critical regulator in neuronal signaling, cognition, and behavior, exists as two isozymes GSK-3α and GSK-3β. Their distinct biological functions remains largely unknown. Here, we examined the evolutionary significance of each of these isozymes. Surprisingly, we found that unlike other vertebrates that harbor both GSK-3 genes, the GSK-3α gene is missing in birds....
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