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Article

The transcriptional response to tumorigenic polarity loss in Drosophila.

eLife - 26 Feb 2015

Bunker Brandon D, Nellimoottil Tittu T, Boileau Ryan M, Classen Anne K, Bilder David

Abstract excerpt

Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains unclear. The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic i...

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Identifiers

PMID: 25719210
DOI: 10.7554/eLife.03189
PMCID: PMC4369581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25719210-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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