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Article

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

26 Nov 2012

Abstract excerpt

Histone deacetylases (HDACs) are currently being discussed as promising therapeutic targets to treat neurodegenerative diseases. However, the role of specific HDACs in cognition and neurodegeneration remains poorly understood. Here, we investigate the function of HDAC6, a class II member of the HDAC superfamily, in the adult mouse brain. We report that mice lacking HDAC6 are cognitively normal but reducing...

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Share to Alzheimer's disease research and treatments
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PMID: 23184605
DOI: 10.1002/emmm.201201923

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