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The Role of HDAC6 in Alzheimer's Disease

17 Dec 2012

Abstract excerpt

The expression of histone deacetylase 6 (HDAC6)--a versatile enzyme with a known role in epigenetics--increases significantly in the hippocampus and other relevant brain regions in both patients with Alzheimer's disease (AD) and animal models of AD. However, when and how HDAC6 expression increases during the course of AD progression remains unclear. Whether HDAC6 overexpression is an underlying cause of AD or a...

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PMID: 22936009
DOI: 10.3233/jad-2012-120727

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