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Article

Neuroprotective Functions for the Histone Deacetylase SIRT6.

Cell reports - 28 Mar 2017

Kaluski Shai, Portillo Miguel, Besnard Antoine, Stein Daniel, Einav Monica, Zhong Lei, Ueberham Uwe, Arendt Thomas, Mostoslavsky Raul, Sahay Amar, Toiber Debra

Abstract excerpt

The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that brain-specific SIRT6-deficient mice survive but present behavioral defects with major learning impairments by 4 months of age. Moreover, the brains of these mice show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28355558
DOI: 10.1016/j.celrep.2017.03.008
PMCID: PMC5389893

Genes

SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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