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Article

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

29 Jan 2013

Abstract excerpt

Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of neurodegenerative diseases. Such results were mainly associated with the epigenetic modulation caused by HDACs, especially those from class I, via chromatin deacetylation. However, other mechanisms may contribute to the neuroprotective effect of HDAC inhibitors, since each HDAC may present distinct specific functions...

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PMID: 23356410
DOI: 10.1186/1750-1326-8-7

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