Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.

doi:10.1371/journal.pgen.1005573

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Article

Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.

PLoS genetics - 1 Oct 2015

Hochner Hagit, Allard Catherine, Granot-Hershkovitz Einat, Chen Jinbo, Sitlani Colleen M, Sazdovska Sandra, Lumley Thomas, McKnight Barbara, Rice Kenneth, Enquobahrie Daniel A, Meigs James B, Kwok Pui, Hivert Marie-France, Borecki Ingrid B, Gomez Felicia, Wang Ting, van Duijn Cornelia, Amin Najaf, Rotter Jerome I, Stamatoyannopoulos John, Meiner Vardiella, Manor Orly, Dupuis Josée, Friedlander Yechiel, Siscovick David S

Abstract excerpt

Loci identified in genome-wide association studies (GWAS) of cardio-metabolic traits account for a small proportion of the traits' heritability. To date, most association studies have not considered parent-of-origin effects (POEs). Here we report investigation of POEs on adiposity and glycemic traits in young adults. The Jerusalem Perinatal Family Follow-Up Study (JPS), comprising 1250 young adults and their...

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PMID: 26451733
DOI: 10.1371/journal.pgen.1005573
PMCID: PMC4599806

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APOB

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